![]() The fame of the rhino is such that its coming even made a noise in the Spanish, French and Italian regions. In the royal menagerie of Manuel 1st, the perissodactyl attracts curious onlookers who come to look at the beast named Ulysse. No specimen of this kind had set foot in the old Europe for over twelve centuries and the time of the Roman games. May 20, 1515, the Nossa Senhora da Ajuda ship docked on the banks of Belém in Lisbon and the landing of the rhino undoubtedly made the biggest impression. Thus in January 1515, Alfonso de Albuquerque, governor of Portuguese India in Goa, is embarking towards Lisbon among ivory furniture and other prestigious gifts, a rhinoceros, royal gift of Muzaffar Shah II, Sultan of Cambay. The exchanges between representatives of Portuguese monarchy and Indian sultans then become commonplace to resolve conflicts, seal agreements or flatter elites. With its full facade on the Atlantic Ocean, the Portugal and its browsers children, Vasco da Gama in mind, bypass the Cape of Good Hope to set foot on the Indian sand in 1498. Woodcut from around 1515, the Rhinoceros of Albrecht Dürer became a naturalist illustration icon, inspiring many artists until beginning of the twentieth century.From Goa to LisbonIn the heart of the sixteenth century, while trade and merchant ships master seas and oceans, it is extremely common to see these wedges filled with plants, spices and exotic animals to satisfy the curiosity of Europe. ![]() Image details from the RRC Image Gallery: ![]()
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![]() ![]() Retired Army Colonel Earl Hopper, a veteran of World War II, Korea and Vietnam, contends that the information that McCain divulged classified information North Vietnam used to hone their air defense system…McCain told his North Vietnamese captors, “highly classified information, the most important of which was the package routes, which were routes used to bomb North Vietnam. McCain divulged specific military information: he gave the name of the aircraft carrier on which he was based, the number of US pilots that had been lost, the number of aircraft in his flight formation, as well as information about the location of rescue ships… On the other hand, according to one source, McCain’s collaboration may have had very real consequences. It was not “name rank and serial number, or kill me,” as specified by the military code of conduct. They were working him.For his part, McCain acknowledges that the Vietnamese rushed him to a hospital, but denies he was given any “special medical treatment.” However….two weeks into his stay at the Vietnamese hospital, the Hanoi press began quoting him. Pacific Command Admiral McCain was in charge of all US forces in the Pacific including those fighting in Vietnam.The Admiral’s bad boy was used to special treatment and his captors knew that. While his son was held captive in Hanoi, John McCain Jr., from 1968 to 1972, was the Commander-in-Chief of U.S. ![]() McCain’s father, John Jr., and grandfather, John Sr., were both full Admirals. He promised his Vietnamese captors, “I’ll give you military information if you will take me to the hospital.”His Vietnamese capturers soon realized their POW, John Sidney McCain III, came from a well-bred line of American military elites. By McCain’s own account, after three or four days, he cracked. Initially, he was taken to the infamous Hanoi Hilton prison camp, where he was interrogated. McCain gave Michael Isikoff a peek at his debriefs, and Isikoff declared there was “nothing incriminating” in them, apart from the redactions. It was the camp that people were released from.”Guy and Larson’s claims are given credence by McCain’s vehement opposition to releasing the government’s debriefings of Vietnam War POWs. As Larson said, “My only contention with the McCain deal is that while he was at The Plantation, to the best of my knowledge and Ted’s knowledge, he was not physically abused in any way. If you choose to do business with this business, please let the business know that you contacted BBB for a BBB Business Profile.Īs a matter of policy, BBB does not endorse any product, service or business.Filed under: 2008 election, cover-up, history, interesting, McCain, news, politics, prison camps, troops, Uncategorized, war, war atrocities, war profiteering Related: More 2008 Election Posts John McCain: Prisoner of War – A First Person Account – US News & World Report from 1973, published online 1/28/08 My six years of hell: John McCain recalls life a prisoner of war in Vietnam – Daily Mail, UK 2/8/08 Excerpt from “Faith of My Fathers” by McCain “Hero” John McCain as Phony and Collaborator: What Really Happened When He Was a POW? – CounterPunch 6/13/08 EXCERPTS: “on March 25, 1999, two of his fellow POWs, Ted Guy and Gordon “Swede” Larson told the Phoenix New Times that, while they could not guarantee that McCain was not physically harmed, they doubted it. 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BBB Business Profiles may not be reproduced for sales or promotional purposes.īBB Business Profiles are provided solely to assist you in exercising your own best judgment. ![]() ![]() ![]() is the center of American politics, with all three branches of the federal government located in the city. is known for its unique style of half-smoke sausages, as well as its seafood, Ethiopian, and Vietnamese cuisine. ![]() The city is also renowned for its cuisine, which reflects the diversity of its population. It is home to numerous museums, galleries, and theaters, many of which are located on or near the National Mall. is a diverse and multicultural city, with a rich history and a vibrant cultural scene. The city receives an average of 39 inches (990 mm) of precipitation per year, which is fairly evenly distributed throughout the year. The average temperature in July, the hottest month, is around 80☏ (27☌), while the average temperature in January, the coldest month, is around 38☏ (3☌). has a humid subtropical climate, with hot summers and mild winters. The quadrants are further divided into neighborhoods, many of which have distinct identities and cultures. The city is divided into four quadrants, named Northeast, Northwest, Southeast, and Southwest, by the intersection of North Capitol Street and East Capitol Street. The city covers an area of 68.34 square miles (177.0 km2), with a population of approximately 705,000 people. ![]() is situated on a plateau that rises from the Potomac River to the east, to a ridge line of hills that stretch to the west. It was also at the center of several major events in American history, including the Civil Rights Movement and the Watergate scandal, which ultimately led to the resignation of President Richard Nixon. In the second half of the 20th century, the city faced many challenges, including urban decay and political corruption. It also became an important center for international diplomacy, hosting numerous embassies and the headquarters of organizations such as the World Bank and the International Monetary Fund. saw a period of growth and expansion, with the construction of numerous government buildings, including the White House, the Capitol building, and the Lincoln Memorial. In the 19th and early 20th centuries, Washington D.C. Today, this design is still evident in the layout of the city. His design included broad, diagonal avenues that intersected with each other, creating numerous open spaces and vistas. The city was designed by French architect Pierre Charles L’Enfant, who modeled it after European cities, such as Paris and Rome. It was named after George Washington, the first president of the United States, and Christopher Columbus. The city was founded in 1791, as a compromise between southern and northern states over where the capital of the newly formed United States should be located. was originally inhabited by Native American tribes, such as the Piscataway and the Nacotchtank, before it was colonized by European settlers in the 17th century. It is located on the east coast of the country, bordered by the states of Maryland to the north, east, and west, and Virginia to the south. Washington D.C., also known as the District of Columbia, is the capital city of the United States of America. ![]() ![]()
![]() ![]() in 1993 with an intratumorally applied liposomal formulation of immunotherapeutic DNA encoding for HLA (human leukocyte antigen)-B7. It is worth mentioning that the first clinical trial ever using in vivo gene transfer was conducted by Nabel et al. ![]() As depicted in Figure 1, such strategies aim (i) to deliver tumor-related antigen plus adjuvant to antigen presenting cells (APC) like dendritic cells (DC) that induce tumor-specific immune responses, (ii) to either deplete or reprogram tumor-induced/expanded immunoregulatory cell types, especially regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC), which collectively inhibit the induction of adaptive immune reactions in the periphery, (iii) to generate tumor-specific T cells and natural killer (NK) cells by genetic introduction of synthetic antigen receptors, termed CARs (chimeric antigen receptors), and (iv) at the tumor site itself to yield direct tumor cell killing, and to inhibit the tumor-promoting function of the tumor microenvironment (TEM). This review aims to present a comprehensive overview of the current state of nucleic acid-based anti-tumor therapeutics, and associated optimization strategies. In this regard, nucleic acid-based immunotherapeutic approaches have received growing interest. Nanotechnology-based strategies, and in particular therapeutic nucleic acids, as well as combined immunotherapies may improve the therapeutic outcome in more patients for a broad range of tumors, even in late stage. However, still only a limited number of patients respond to the already approved immunotherapies, and toxicity as well as induction of resistance towards treatment are often a problem. As a consequence of a better understanding of the tumor as a heterogeneous tissue with different types of cells, new strategies for cancer therapy have been developed, which are also applicable in combination with classical therapies. In the last 20–30 years, however, cancer treatment regimens have changed remarkably, based on the gained knowledge about molecular biology as well as tumor pathobiology and pathophysiology. Moreover, the patients often suffer from severe side-effects. The main reasons for therapy failure are chemoresistance as well as metastasis. Conventional treatments (surgery, chemotherapy, and irradiation) are often inefficient, resulting in recurrence and even death. Depending on the tumor type, stage, and location, cancer therapy can be very challenging. ![]() Aside from further improvements of individual nucleic acid-based drugs, the major perspective for successful cancer therapy will be combination treatments employing conventional regimens as well as immunotherapeutics like checkpoint inhibitors and nucleic acid-based drugs, each acting on several levels to adequately counter-act tumor immune evasion.Ĭancer is a serious and life-threatening disease with increasing incidence in today’s world. This review intends to provide a comprehensive overview of the current state of the therapeutic use of nucleic acids for cancer treatment on various levels, comprising (i) mRNA and DNA-based vaccines to be expressed by antigen presenting cells evoking sustained anti-tumor T cell responses, (ii) molecular adjuvants, (iii) strategies to inhibit/reprogram tumor-induced regulatory immune cells e.g., by RNA interference (RNAi), (iv) genetically tailored T cells and natural killer cells to directly recognize tumor antigens, and (v) killing of tumor cells, and reprograming of constituents of the tumor microenvironment by gene transfer and RNAi. Furthermore, especially in the context of the development of biocompatible, cell type targeting nano-carriers, nucleic acid-based drugs aimed to initiate and to enhance anti-tumor responses have come of age. Within the last decade, the introduction of checkpoint inhibitors proposed to boost the patients’ anti-tumor immune response has proven the efficacy of immunotherapeutic approaches for tumor therapy. ![]() ![]() There are a limited number of rooms available and will be reserved on a first come, first serve basis.Īdditionally you can also check for discounted rates outside of the above dates by using the promo code: HOME. So book your Great Wolf Lodge trip early to ensure that you secure a room. Please note that these great rates are subject to availability and tend to book quickly. You may also choose to make your reservation for Great Wolf Lodge online at using the same promo code. In order to take advantage of these great discounted rates please simply call just call the Great Wolf Lodge central reservations department at 1-80, and provide them with the PROMO CODE: HOMEM. *$14.99 resort fee and 9% occupancy tax will be added to the final price for each room Kid Cabin Suite (sleeps 7): $229 per room If you’re looking to go a little further, check out our stories on Traveling with Kids to LA and Traveling with Kids to San Diego.The rates run from 9/8/13 to 10/31/13 (exculding Columbus Day) and again from 12/1/13 to 12/19/13 and are valid Sunday through Thursday only with some restrictions. This is a great close to home adventure if you’re in the NYC area. Coffee at the ready right down the hall from the water park, arcade and bowling alley! Top 3 Things About The Great Wolf Lodge PAġ- The Water Park- This is hands down the best feature of GWL.Ģ- MagiQuest Adventure- Once your little adventurer gets their wand (and maybe cape), they get to become their own live-action star and run around the hotel to solve a quest.ģ- Dunkin Donuts- Sorry to admit it, but this is a highlight of the lodge for the parents. I did see a lot of families with babies (floating in the pool mostly) but for kids above 4, they could truly enjoy everything from the bowling and mining to the arcade and Build-A-Bear Workshop. For littles, you’ll need to be hand holding (and swimming) with them, but for kids over 8 you can give them a lot of freedom to slide and swim amongst themselves. This place is great for kids ages 4 and up. There are seasonal deals, all-in-one deals, early saver deals as well as a Howling Heroes Discount for first responders. GWL has so many deals, make sure you check their deals page. It comes with a round of mini-golf and bowling, a MagiQuest wand, a Build a Bear animal and more. River Canyon Run and Totem Towers are for all ages, while the drops on Coyote Canyon and the Double Barrel Drop are fierce enough even for teens! Great Wolf Lodge Day PassĪll room stays give you access to the water park! But I recommend going for the upgraded day passes. ![]() For the bigger kids, set them loose in Fort Mackenzie (a four-story fort treehouse) and watch them take turns on the biggest, baddest water slides. This land of water has a lazy river, kiddie pool and a water playground for parents with babies or little kids. ![]() Ready to see your kids have the time of their lives? Well get ready! The Great Wolf Lodge Water Park is amazing. You are definitely not at Great Wolf Lodge for the rooms, but for the fun! Great Wolf Lodge Water Park The rooms are pretty basic, but great for kids and families. ![]() These are great for families having reunions and friends doing big get togethers. There are suits with balconies and fireplaces, as well as large suites that sleep up to 12 people. We stayed in a Wolf Den Suite, which is a themed suite that sleeps 6 and has a cozy sleeping den with bunkbeds for the kids. Being near the city, you can expect to meet lots of other families from NYC and surrounding areas. Where is Great Wolf Lodge?Īt under 90 miles from NYC, families looking for an indoor water park can be on the slides at Great Wolf Lodge in less than two hours. ![]() Whether you’re after skiing, rafting, hiking or boating, there’s so much to do in the Poconos every season of the year. The Pocono, PA location is located near all the fun of the Poconos. Up to 30 military discount for active duty, VETERANS, retired military, military spouses, and first responder families On the Great Wolf Lodge website. Great Wolf Lodge Water Park Pocono Mountains There are also 19+ Great Wolf Lodge locations across the country. Since we’re in NY, we were lucky to have a Great Wolf Lodge within two hours of our house. Top 3 Things About The Great Wolf Lodge PA.Great Wolf Lodge Water Park Pocono Mountains. ![]() ![]() ![]() Each of the Premier category hotels comes with complimentary Universal Express Unlimited passes for your entire party staying at the hotel.Īll Universal Orlando hotels provide complimentary transportation to and from its theme parks and Early Park Admission, which allows your party to get into the theme parks one hour before the regularly scheduled opening time. Universal Studios Singapore vacation package deals Remove all filters Peninsula Excelsior Hotel Downtown Singapore 709 561 per person Sep 12 - Sep 15 Roundtrip flight included Manila (MNL) to Singapore (SIN) 2 outdoor pools, a spa tub, and a gym are all featured at this hotel. Its sister property, Dockside Inn and Suites, will offer another affordable option when it opens.įor a more luxurious hotel experience, Universal Orlando offers three Premier category hotels including Loews Portofino Bay Hotel, Hard Rock Hotel at Universal Orlando and Loews Royal Pacific Resort. Universal Orlando has launched its first-ever Value category hotel: Universal’s Endless Summer Resort – Surfside Inn and Suites, with room rates beginning around $100. If you are looking for a budget-friendly hotel, you are in luck. SPECIAL SAVINGS For a limited time, get 3 days FREE with the purchase of 2-Day tickets. Book A Universal Studios Vacation Package The Wizarding World of Harry Potter- Exclusive Vacation Package Venture into a world where magic is real and excitement knows no bounds at The Wizarding World of Harry Potter, at Universal’s Islands of Adventure theme park. ![]() You can choose a hotel from eight options that include standard rooms and a multitude of suites to accommodate every style, size and budget. AAA members get exclusive benefits on 3-night or longer vacation packages, including 50 savings1, early park admission, Free Universal Express Unlimited. Make your Florida vacation one to remember with a stay at this hotel and theme park complex.Ī visit to Universal Orlando Resort offers a memorable vacation for all the family, with accommodation, entertainment and theme park thrills all in one place. ![]() ![]()
![]() You have to choose the tanks from various them then, you can customize them by earning the rewards while playing the attack game. The best of the designs and the outlook of every element makes the world a serene environment where you directly get lost in the atmosphere. The designs and the simulation in the ultra HD 3D methods give the users a whole new landscape world to dive into. The gameplay offers the users all the elements of the play in the most detailed description so you can immerse in their outlook. We have below discussed some of the elaborated ones so to help you in the same Serene look graphics and outstanding visuals World of Tanks Blitz Mod Apk offers the users the specialized functions and the notable features to explore the gaming of intense battles. Anti-ban, antivirus, no lagging, fixed bugs, and more make the version safe and secure to play on with and immerse in the beautiful gaming world. There are no ads in the gameplay of this modified version, and it doesn't require rooting from any source while installing it. Free shopping is integrated so you can purchase any equipment and tool you want for the uplifted battles. The performance offers the users unlimited money and coins to upgrade and enhance the tools, weapons, tanks, power, etc., unlocked various tanks, famous brands, routes, location landscape, armies, and more. The mod version is available on our website, which you can download from the given below link these pages. World of Tanks Blitz Mod Apk is an alternate and modified variant of the original application. The ultra HD 3d simulation of the wars will make your battle experience epic. ![]() Play with random strangers from vivid parts of the world and make them allies or opponents. In the multiplayer combat system, you can bring on your friends and form platoons to attack combined. Alex Tech has designed the advanced elements to face everything in enhancement you will explore a variety of battlegrounds in air and sea routes units. You will take on with your tanks on the war's ground directly where you have to start the attacking and defending process in the modes. You can then explore many locations and landscapes of the wars as we know, the tank is an attacking and defensive shield weapon that acts as armor also. Instead, you need to earn rewards and then unlock the best ones. Every tank is not available to play with. Massive availability of tanks from famous wars, different formats, attack methods, vivid outlooks, ad their variant is available to choose as per your wish. You can come and join the game where all you have to do is to get the tanks of your choice on the command. Here, we have this World of Tanks Blitz Mod Apk, which lets everyone explore the real war battles in the multiplayer feasibility. ![]() Now the games are uncovered in fighting, combat, and multiplayer, which brings to everyone the real war kind of feeling due to mechanism. ![]() We always had the fantasy to explore the wars from the proximity being young means we have a lot of energy and aggressiveness, so a lot more people at their young age love to release their hostility through the format of the battle. ![]() |
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